The experts at NEXTREAT Laboratories regularly perform OECD 414 (Prenatal Developmental Toxicity / DART) studies.
To provide uniquely optimal services, NEXTREAT developed a system allowing for the compete, image-based documentation of DART studies.
NEXTREAT’s system has numerous advantages over the “classical” manual inspection of Alizarin red / Alcian blue staind specimen, such as…
1) Significantly improves the quality/resolution of material necessary for the visual inspection, also in difficult to assess areas
2) Enables the possibility of peer review or the review by distant/external experts,
3) Minimizes the danger of the damaging of the specimen during inspection,
4) Since data are stored digitally, this method can replace the extended storage of the biological specimen
5) …
Below, some of exemplary images and videos are presented, giving an impression on the quality of the data.
1) Rat embryo with open thorax for optimal visual assessment by an expert.
A tool has been developed, which allows a quick and easy manual navigation, zooming and annotation of the digital documentation.
Click on one of the images for viewing of video.
Whole embryo with thorax opened Segment displaying the thoracic region only
2) Rat embryo with unopened chest for optimal preservation of anatomy and as basis for subsequent 3D reconstruction.
Click on one of the images for viewing of video.
Whole embryo Video of the head to demonstrate the resolution
3) 3D reconstructed embryo (under development)
Click on the image below for viewing of videos.
Whole body reconstruction (bones and cartilage) 3D reconstruction of thoracic region (bones only)
Elevate your next project requiring DART testing to a whole new level, and contact us for expertise.